Effectiveness of Spiritual-Based Interventions in Enhancing Quality of Life Among Breast Cancer Patients: A Systematic Review
Keywords:
breast cancer, quality of life, spiritual intervention, Spiritual CareAbstract
Breast cancer is the most prevalent cancer among women and significantly affects patients' quality of life. Beyond physical symptoms, patients often experience emotional and social burdens that deteriorate their overall well-being. While medical and psychosocial interventions are widely applied, spiritual aspects are often underemphasized. Therefore, spiritual-based interventions are needed to support recovery by fostering hope, emotional stability, and a sense of life meaning.To explore the effectiveness of spiritual-based interventions in improving the quality of life of breast cancer patients. This study employed a systematic review design. Articles were retrieved from three databases CINAHL, PubMed, and Scopus using the main keywords: “breast cancer,” “quality of life,” “spiritual care,” and “spiritual intervention.” Inclusion criteria were original research articles, written in English, published between 2011 and 2025, and involving breast cancer patients. Data were extracted using structured tables and analyzed descriptively using qualitative synthesis. Seven eligible studies demonstrated that spiritual-based interventions, such as prayer, group therapy, meditation, and religious counseling, positively affect the quality of life of breast cancer patients. Key outcomes included enhanced hope, reduced pain, improved emotional, physical, and social well-being, stronger spiritual resilience, better coping mechanisms, and increased social support through group-based activities. Spiritual-based interventions significantly improve the quality of life of breast cancer patients through a holistic approach, integrating physical, emotional, social, and spiritual dimensions.
Downloads
References
Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 Feb 4;71.
Park S, Sato Y, Takita Y, Tamura N, Ninomiya A, Kosugi T, et al. Mindfulness-Based Cognitive Therapy for Psychological Distress, Fear of Cancer Recurrence, Fatigue, Spiritual Well-Being, and Quality of Life in Patients With Breast Cancer—A Randomized Controlled Trial. J Pain Symptom Manag 60(2), 381–389. 2020;
Hashemi S-. M, Rafiemanesh H, Aghamohammadi T, Badakhsh M, Amirshahi M, Sari M. Prevalence of anxiety among breast cancer patients: a systematic review and meta-analysis. Breast Cancer [Internet]. 2020;27. Available from: https://doi.org/10.1007/s12282-019-01031-9
Cheng ASK, Liu X, Ng PHF, Kwok CTT, Zeng Y, Feuerstein M. Breast cancer application protocol: a randomised controlled trial to evaluate a self-management app for breast cancer survivors. BMJ Open. 2020;10(7):e034655–e034655.
Nápoles AM, Santoyo-Olsson J, Stewart AL, Ortiz C, Samayoa C, Torres-Nguyen A, et al. Nuevo Amanecer-II: Results of a randomized controlled trial of a community-based participatory, peer-delivered stress management intervention for rural Latina breast cancer survivors. Psychooncology. 2020 Nov;29(11):1802–14.
Santa-Maria CA, Coughlin JW, Sharma D, Armanios M, Blackford AL, Schreyer C, et al. The Effects of a Remote-based Weight Loss Program on Adipocytokines, Metabolic Markers, and Telomere Length in Breast Cancer Survivors: the POWER-Remote Trial. Clin cancer Res an Off J Am Assoc Cancer Res. 2020 Jun;26(12):3024–34.
Lally RM, Kupzyk KA, Bellavia G, Hydeman J, Gallo S, Helgeson VS, et al. CaringGuidanceTM after breast cancer diagnosis eHealth psychoeducational intervention to reduce early post-diagnosis distress. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2020;28(5):2163–74.
Bjelic-Radisic V, Cardoso F, Cameron D, Brain E, Kuljanic K, Costa RA, et al. An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients: EORTC QLQ-BR45. Ann Oncol. 2020;31.
Oner Cengiz H, Bayir B, Sayar S, Demirtas M. Effect of mindfulness-based therapy on spiritual well-being in breast cancer patients: a randomized controlled study. Support Care Cancer [Internet]. 2023;31(7):438. Available from: https://doi.org/10.1007/s00520-023-07904-2
Borges M, Caldeira S, Loyola-Caetano E, Magalhães P, Areco F, Panobianco M. Spiritual/Religious coping of women with breast cancer. Religions [Internet]. 2017;8. Available from: https://doi.org/10.3390/rel8110254
Jafari N, Zamani A, Farajzadegan Z, Bahrami F, Emami H, Loghmani A. The effect of spiritual therapy for improving the quality of life of women with breast cancer: A randomized controlled trial. Psychol Heal Med 18(1), 56–69. 2013;
Zamaniyan S. Effectiveness of spiritual group therapy on quality of life and spiritual well-being among patients with breast cancer. Iran J Med Sci. 2016;41.
Gall TL, Bilodeau C. The role of positive and negative religious/spiritual coping in women’s adjustment to breast cancer: A longitudinal study. J Psychosoc Oncol [Internet]. 2020;38. Available from: https://doi.org/10.1080/07347332.2019.1641581
Sabzichi M, Mohammadian J, Mohammadi M, Jahanfar F, Movassagh Pour AA, Hamishehkar H, et al. Vitamin D-Loaded Nanostructured Lipid Carrier (NLC): A New Strategy for Enhancing Efficacy of Doxorubicin in Breast Cancer Treatment. Nutr Cancer. 2017;69(6):840–8.
Farias A. Exploring the role of physician communication about adjuvant endocrine therapy among breast cancer patients on active treatment: a qualitative analysis. Support Care Cancer. 2017;25.
Kokkonen K, Kellokumpu-Lehtinen P-L, Kankaanpää M, Nikander R, Penttinen HM, Utriainen M, et al. Factors predicting long-term physical activity of breast cancer survivors. 5-year-follow-up of the BREX exercise intervention study. Acta Oncol (Madr) [Internet]. 2022;61(10):1200–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134795859&doi=10.1080%2F0284186X.2022.2103388&partnerID=40&md5=30a36e6aadb7f711db480dd60c4b8285
Delgado-Rodríguez M, Sillero-Arenas M. Systematic review and meta-analysis. Med intensiva. 2018 Oct;42(7):444–53.
Khezri E, Bagheri-Saveh MI, Kalhor MM, Rahnama M, Roshani D, Salehi K. Nursing care based on the Support-Based Spiritual Care Model increases hope among women with breast cancer in Iran. Support Care Cancer [Internet]. 2022;30(1):423–9. Available from: https://doi.org/10.1007/s00520-021-06413-4
Jahanizade MR, Shahriari M, Alimohammadi N. Effect of Spiritual Care on Pain of Breast Cancer Patients : A Clinical Trial. 2018;6(1):47–53.
Momennasab M, Ghorbani F, Yektatalab S, Magharei M, Tehranineshat B. The Effect of Spiritual Group Therapy on the Quality of Life and Empowerment of Women with Breast Cancer: A Randomized Clinical Trial in Iran. J Relig Health [Internet]. 2024;63(2):1504–22. Available from: https://doi.org/10.1007/s10943-024-02009-4
Zamaniyan S, Bolhari J, Naziri G, Akrami M, Hosseini S. Effectiveness of spiritual group therapy on quality of life and spiritual well-being among patients with breast Cancer. Iran J Med Sci. 2016;41.
Ghahari S, Fallah R, Rad MM, Farrokhi N, Bolhari J, Mousavi M, et al. Effect of cognitive-behavioral therapy and spiritual-religious intervention on improving coping responses and quality of life among women with breast cancer in Tehran. Bali Med J. 2017;6(2):409.
Farajzadegan Z, Zamani A, Bahrami F, Emami H, Loghmani A, Jafari N. Spiritual Therapy to Improve the Spiritual Well-Being of Iranian Women with Breast Cancer: A Randomized Controlled Trial. Evidence-Based Complement Altern Med 2013, 1–9. 2013;
Momennasab M, Ghorbani F, Yektatalab S, Magharei M, Tehranineshat B. The Effect of Spiritual Group Therapy on the Quality of Life and Empowerment of Women with Breast Cancer: A Randomized Clinical Trial in Iran. J Relig Health [Internet]. 2024;63(2):1504–22. Available from: https://doi.org/10.1007/s10943-024-02009-4
Ghahari S, Fallah R, Rad M, Farrokhi N, Bolhari J, Mousavi M. Effect of cognitive-behavioral therapy and spiritual-religious intervention on improving coping responses and quality of life among women with breast cancer in Tehran. Bali Med J [Internet]. 2017;6. Available from: https://doi.org/10.15562/bmj.v6i2.581
Harry ML, Chrenka EA, Freitag LA, Saman DM, Allen CI, Asche SE, et al. Primary care clinicians’ opinions before and after implementation of cancer screening and prevention clinical decision support in a clinic cluster-randomized control trial: a survey research study. BMC Health Serv Res. 2022 Jan;22(1):38.
Wolfs J, Beugels J, Kimman M, Piatkowski de Grzymala AA, Heuts E, Keuter X, et al. Improving the quality of life of patients with breast cancer-related lymphoedema by lymphaticovenous anastomosis (LVA): study protocol of a multicentre randomised controlled trial. BMJ Open. 2020 Jan;10(1):e035337.
Nissen ER, O’Connor M, Kaldo V, Højris I, Borre M, Zachariae R, et al. Internet-delivered mindfulness-based cognitive therapy for anxiety and depression in cancer survivors: A randomized controlled trial. Psychooncology. 2020 Jan;29(1):68–75.
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, et al. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutr Res. 2020 Jul;79:77–86.
Sho S, Yothers G, Colangelo LH, Ganz PA, O’Connell MJ, Beart RWJ, et al. Assessing the Quality of Rectal Cancer Pathology Reports in National Surgical Adjuvant Breast and Bowel Project Protocol R-04/NRG Oncology. Dis Colon Rectum. 2020 Aug;63(8):1063–70.
Hou I-C, Lan M-F, Shen S-H, Tsai PY, Chang KJ, Tai H-C, et al. The Development of a Mobile Health App for Breast Cancer Self-Management Support in Taiwan: Design Thinking Approach. JMIR mHealth uHealth. 2020;8(4):e15780–e15780.
Henneghan AM, Becker H, Harrison ML, Inselmann K, Fico B, Schafer H, et al. A randomized control trial of meditation compared to music listening to improve cognitive function for breast cancer survivors: Feasibility and acceptability. Complement Ther Clin Pract. 2020 Nov;41:101228.
Ream E, Hughes AE, Cox A, Skarparis K, Richardson A, Pedersen VH, et al. Telephone interventions for symptom management in adults with cancer. Cochrane database Syst Rev. 2020;6(6):CD007568–CD007568.
Jafari N, Farajzadegan Z, Zamani A, Bahrami F, Emami H, Loghmani A. Spiritual well-being and quality of life in Iranian women with breast cancer undergoing radiation therapy. Support Care Cancer [Internet]. 2013;21. Available from: https://doi.org/10.1007/s00520-012-1650-1
Culbertson MG, Bennett K, Kelly CM, Sharp L, Cahir C. The psychosocial determinants of quality of life in breast cancer survivors: A scoping review. BMC Cancer [Internet]. 2020;20. Available from: https://doi.org/10.1186/s12885-020-07389-w
Lim M, Ang B, Lam C, Loh E, Zainuddin S, Capelle D. The effect of 5-min mindfulness of love on suffering and spiritual quality of life of palliative care patients: a randomized controlled study. Eur J Cancer Care. 2021;30.
Ashing KT, George M. Exploring the efficacy of a paraprofessional delivered telephonic psychoeducational intervention on emotional well-being in African American breast cancer survivors. Support Care Cancer [Internet]. 2020;28(3):1163–71. Available from: http://10.0.3.239/s00520-019-04899-7
Hou I-C, Lin H-Y, Shen S-H, Chang K-J, Tai H-C, Tsai A-J, et al. Quality of Life of Women After a First Diagnosis of Breast Cancer Using a Self-Management Support mHealth App in Taiwan: Randomized Controlled Trial. JMIR mHealth uHealth. 2020;8(3):e17084–e17084.
Novakov I. Emotional state, fatigue, functional status and quality of life in breast cancer: exploring the moderating role of psychological inflexibility. Psychol Heal Med [Internet]. 2021;26. Available from: https://doi.org/10.1080/13548506.2020.1842896
Oswald LB, Baik SH, Buscemi J, Buitrago D, Iacobelli F, Guitelman J, et al. Effects of smartphone interventions on cancer knowledge and coping among Latina breast cancer survivors: Secondary analysis of a pilot randomized controlled trial. J Psychosoc Oncol. 2022;40(6):695–707.
Carl E, Shevorykin A, Liskiewicz A, Alberico R, Belal A, Mahoney M, et al. Increasing Physical Activity among Breast Cancer Survivors by Modulating Temporal Orientation with rTMS: Feasibility and Potential Efficacy. Int J Environ Res Public Health. 2021 Sep;18(19).
Akkol-Solakoglu S, Hevey D, Richards D. A randomised controlled trial comparing internet-delivered cognitive behavioural therapy (iCBT) with and without main carer access versus treatment-as-usual for depression and anxiety among breast cancer survivors: Study protocol. Internet Interv [Internet]. 2021;24:100367. Available from: https://www.sciencedirect.com/science/article/pii/S2214782921000075
Takano T, Matsuda A, Ishizuka N, Ozaki Y, Suyama K, Tanabe Y, et al. Effectiveness of self-help workbook intervention on quality of life in cancer patients receiving chemotherapy: results of a randomized controlled trial. BMC Cancer. 2021 May;21(1):588.
Lacouture ME, Dion H, Ravipaty S, Jimenez JJ, Thapa K, Grund EM, et al. A phase I safety study of topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia. Breast Cancer Res Treat. 2021;186(1):107–14.

Published
How to Cite
Issue
Section
Copyright (c) 2025 Hansen Maikel Su, Suhartini Ismail, Awal Prasetyo

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.